The bomber detonated his explosives-laden pick-up truck near the official residence of Balochistan Police chief Mushtaq Sukhera in a high-security area of Quetta last night.
Sukhera, who was returning home from work, escaped unhurt.
Four policemen were among the dead. About 70 people, including 27 policemen, were injured by the powerful blast that created a crater 12 feet deep and seven feet wide.
Buildings within a radius of 1.5 km, including the Governor House, Chief Minister's House, Quetta Press Club, and dozens of shops on Jinnah Road, were damaged by the blast.
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The windows of offices of several media organisations were blown out. The blast also hit members of a political party who were returning from a protest.
Police officials said an estimated 2,000 kg of explosives were used in the attack, for which no group claimed responsibility.
The police officials said the bomber had followed the police chief's motorcade when he returned home from work.
Some reports said the suicide attack was followed by intense firing. It could not be ascertained who had opened fire.
A string of gun and bomb attacks during and after the polling claimed nearly 50 lives.