The 23-year-old singer performed her hit "Stone Cold" without a hitch, but she slipped and fell when she returned to the stage at The Forum in Inglewood, California.
As Lovato made her way down the catwalk and reached down to greet some of the 16,000 students in attendance, she stumbled.
But she didn't let the fall ruin her day with fans, and she simply laughed it off, while also raising her hand in the air, reported Ace Showbiz.
"I'm OK!" she yelled as event personnel helped her off the stage.
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It's the second time Lovato has taken a tumble onstage in a matter of months - she fell over during a 20-minute set at the Z100 Jingle Ball in New York City after tripping over her microphone stand in December last year.
And last summer, she slipped while chatting to fans during a rooftop pool party while promoting her single Cool For the Summer.
Again, she didn't let the mishap ruin her day and she made light of it before jumping into the pool fully clothed to join fans.