"I am outraged by President Trump's executive order banning immigrants and refugees from the United States on the basis of religion. This pronouncement violates constitutional principles and disregards religious tolerance - a cornerstone of American democracy," Congresswoman Barbara Lee said.
Senate Minority Leader Chuck Schumer said this is one of the most backward and nasty executive orders that the President has issued.
"Taking in immigrants and refugees is not only humanitarian but has also boosted our economy and created jobs decade after decade," Schumer said.
"On Holocaust Memorial Day, Trump restricted refugees from Muslim-majority countries. Make no mistake- this is a Muslim ban," said Senator Kamala Harris from California.
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"We have opened our doors to those fleeing violence and oppression for decades, by presidents on both sides of the aisle. We can't turn our backs on the millions of refugees who are contributing to our country and our economy," she said.
"Trump's Muslim ban is a moral abomination. It is fundamentally un-American. And it is dangerous - it will give life back to the terrorist movement and eventually get Americans killed," Murphy said.
Senator Duck Durbin asked Republican lawmakers to reject this ban on Muslims.
"History will judge where America's leaders stood today," he said.
"This is not what America is about. We stand strongly
against these hateful actions, and in solidarity with our Muslim and immigrant neighbours," said Stephanie Taylor, co-founder, Progressive Change Campaign Committee.
"It's despicable that President Trump chose Holocaust Remembrance Day to issue yet another executive order that exploits fear of refugees and immigrants. This is wrong. I will continue to fight the President's extreme, knee jerk actions that divide our country," said Senator Mazie K Hirono.
Describing this as a watershed moment, Lee said people of conscience must unite in opposition to this un-American policy which weakens US leadership on the world stage and poses a direct threat to national security.