De la Renta died last night, a family member confirmed. The Dominican-American designer was diagnosed with cancer in 2006, reported ABC News.
De la Renta was touted as one of the most sought after fashion designers in the world. He was particularly known for his red carpet gowns and evening wear.
His silk-taffeta and chiffon gowns were praised as pieces of art. He recently designed Hollywood superstar George Clooney's wife Amal Alamuddin's wedding gown, which was an ivory beaded-tulle dress.
It was under designer Jane Derby that de la Renta fully launched his label in 1965. His moniker included everything from evening gowns, bridal wear, the fragrance OSCAR, homewares and furnishings.
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He became internationally known in the 1960s as one of the couturiers to dress then US First Lady, Jacqueline Kennedy.
From 1993 to 2002, de la Renta designed the haute couture collection for the house of Balmain, becoming the first Dominican to design for a French couture house. In 2006, the Oscar de la Renta label diversified into bridal wear.
De la Renta married editor-in-chief of French Vogue Francoise de Langlade in 1967. They were married until her death in 1983.
In 1989, the designer married Annette Engelhard, daughter of Franz Mannheimer and Jane nee Reiss. De la Renta had stepchildren from both marriages. He also had an adopted son, Moises de la Renta.
He served on the boards of several charitable institutions such as New Yorkers for Children, the America's Society.