The Dominican-born American fashion icon, who dressed first ladies from Jacqueline Kennedy to Laura Bush, most recently designed the wedding dress for human rights lawyer Amal Alamuddin, who wed Hollywood heart throb George Clooney.
A sophisticated, sartorial choice for A-list movie stars on the red carpet and wealthy socialites, he was also the go-to man for something elegant for actress and fashionista Sarah Jessica Parker, of "Sex and the City" fame.
The designer reportedly passed away at his home in Connecticut but worked right up to the end of his life.
His company website late yesterday bore only his trademark signature in white against a navy blue background.
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De La Renta himself was photographed in October's edition of American Vogue alongside Amal Clooney trying on her wedding dress in his New York studio.
Tributes quickly poured in from around the world mourning the loss of one of America's most eminent designers.
"RIP iconic designer Oscar De La Renta, who was a big part of 3 of my life's biggest moments. Much love and peace 2 his family and all who loved him!" wrote US singer Gloria Estefan on Twitter.
In a career that spanned five decades, de la Renta saw his company grow into a multi-million-dollar empire that included ready to wear, fragrance, a home line and a bridal collection, which he launched in 2006.