India were put into bat after skipper Mahendra Singh Dhoni lost the toss in an overcast and chilly morning.
If South Africa can chase down the Indian total, it will be a record at this venue. The highest successful chase here is 258 for three by Australia against Pakistan in a NatWest series match in 2001.
Interestingly, all the seven completed ODIs here have been won by the team batting second.
That blemish apart, Dhawan was the toast of the Indian crowd, almost 70 per cent of the 16000-strong turnout.
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After he got his eye in, the Delhi batsman batted with gay abandon, often stepping out to find the little gaps in a tight off-side field. When he was on 45, Dhawan was struck on his helmet after failing to shy away from a Ryan McLaren bouncer.
After Sharma got out for 65, Dhawan featured in a 83-run second wicket partnership with Virat Kohli (31 off 41 balls) as he held the innings together till he perished in the 38th over trying to sweep Duminy but only managing to find substitute fielder Aaron Phangiso at square leg.
Interestingly, in the last six years only two left-handers have made ODI hundreds against the South Africans. Kumar Sangakkara did it in Johannesburg in January 2012 and it was Dhawan's turn today.