The 35-year-old actor was speaking at TIFF Soiree's Share Her Journey segment organised by Toronto International Film Festival.
The snippets of the tete-a-tete were tweeted from TIFF's official account.
"When the opportunity came my way (to work in America), I saw it as an opportunity to break the ceiling for actors that look like me.
"Once I was asked not to be a part of a cast because I was too ethnic... I didn't realise how hard it was until I came to North America," Priyanka said.
More From This Section
She added the ABC show, which has been renewed for a third season, "started a conversation about what terrorists are (supposed to) looks like".
Talking about her journey in films, Priyanka said there was a time when filmmakers dropped her due to difference in opinion, which came with her being a woman.
"I've had people take away films from me because I might not have agreed with them," she said.
The actor also discussed her critically-acclaimed films such as "Fashion" and "Mary Kom".
"'Mary Kom' was a challenging movie, which excited me even more. Give me something difficult and I'll always say yes," she said.
Priyanka won the National Film Award for best actress for the Madhur Bhandarkar-directed film.
On the red carpet of the 42nd annual film festival, the actor praised "Wonder Woman" director Patty Jenkins for helming a studio superhero film.
"You can understand how hard and few and far between these opportunities are. But it's got to take people like us to stand out there, dig our heels in and say we're not going to stand for it anymore," Priyanka told CBC Toronto.
The actor was present at the festival for the screening of her maiden Sikkimese production, "Pahuna".