The outbreak of diphtheria, which affects membranes of the throat and nose, has caused concern in the health sector as the disease can be prevented through immunisation.
It had been eradicated completely from the state through vaccination and immunisation programmes years ago.
But the death of Ameeruddin, a 12 year-old-boy from Kondotty in Malappuram on September 17 had confirmed the return of diphtheria in the state, health department officials said.
"Northern districts Malappuram and Kasaragod are lagging behind in immunisation in the state. Unwillingness of parents had prevented health officials to administer vaccine to children there," he said.
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He said it was unfortunate that the right of children to get immunised was denied due to superstition and false propaganda.
The minister also said the department would initiate intense awareness programmes to make people understand the need to get their children take preventive vaccines.
As part of the drive, the second phase of preventive vaccination programme would begin in Malappuram on October 1, he said.
The reports of the return of diphtheria in Kerala, known for its high health indices and standard of living, has come as a shock to the state public health sector.
The Indian Medical Association had termed the boy's death as 'shocking' and 'public health disaster'.