The unseeded Indian pair lost 2-6 2-6 to formidable Uruguay-Spanish combo in the euro 485,760 clay court event.
Left-handed Divij and Raja paid the price for not cashing in on the opportunities they had since they converted just one of the four breakpoints they got in the match.
The top seeds though were clinical converting five of the sixes break chances.
Indian challenge is alive in the women's event with Sania Mirza and Cara Black progressing to the semifinals with a 6-3 6-4 win over Silvia Soler-Espinosa and Shuai Zhang.