The 29-year-old world number two makes his bow in the tournament on Tuesday, his first match since tumbling out in Melbourne last month in the second round against Uzbekistand's Denis Istomin.
The Australian Open defeat was the nadir of a challenging dip in form for the Serbian former world number one, who has won only two titles since July last year.
Djokovic, who is making his debut in Acapulco, said he feels in a healthier frame of mind since his travails of recent months.
Djokovic, who plays Slovakia's Martin Klizan in the first round, admitted going out in Melbourne so early had come as a shock.
More From This Section
"I haven't experienced the first-week Australian Open loss for many years," said Djokovic.
"But it's kind of normal and expected to go through those times when you're not playing as best as you can maybe, as best as you want to be, or maybe the opponent has an amazing day. It's sport. You have to deal with it, and you can always learn much more from the losses."
Fifth seed David Goffin had no such difficulty however, breezing past France's Stephane Robert 6-1, 6-2.