Serbia's Djokovic pushed his career record against the Scot to 18-8, adding the triumph in the championship match on the hardcourts of Miami to victories over Murray this year in the Australian Open final and the semi-finals of the Indian Wells Masters.
"I could not ask for a better start of the season, winning three big titles," Djokovic said. "Hopefully I'm able to use this for the claycourt coming up. That's extremely important for me obviously leading up to French."
On Monday, Djokovic will tie Spain's Rafael Nadal for the sixth-most weeks spent at the top of the rankings, sitting atop the summit for the 141st week in his career.
Murray, meanwhile, is poised to return to number three in the world.
The Scot, whose last victory over Djokovic was in his historic Wimbledon final triumph of 2013, started strong in a bid to end a six-match skid against the Serb.
- Brutal conditions -
=====================
The two traded four breaks of serve in the first eight games of the tense first set in which both struggled on serve on one sun-splashed end of the court.
"We tried to stay mentally tough, both of us, and kind of hang in there, battle, and wear down the other player physically.
"There were lots of exchanges, a lot of long rallies. I was expecting that coming into the match, but one thing is to really expect and the other is to really experience it and really go through it on the court."
Djokovic was quick to seize the initiative in the tiebreaker, racing to a 4-0 lead, and despite a double fault Djokovic had quickly wrapped up the decider 7/3.
A frustrated Djokovic barked at those in his box on the change over, startling a nearby ball kid and earning a warning from the chair umpire.
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