Clark's disappearance is one of the oldest active missing-person cases in the United States, according to a federally funded database of missing persons.
Investigators know Clark is not alive he'd be more than 160 years old but they believe they have his remains. Now, they need DNA samples from Clark's hard-to-find descendants to close the case.
Despite the age of the remains, investigators were able to get a good DNA profile, said Dr. Nici Vance of the Oregon state medical examiner's office. Volunteer genealogists then found three great-great-grandchildren on the paternal side.
"There's an association there, but it's not strong at this point." Vance entered Clark's name into the database of the National Missing and Unidentified Persons System, which provides a central repository of information about missing persons and unidentified decedent records.
"There might have been an item of jewelry that was found with that person that could trigger a memory of a family member," she said.