The former 'X Factor' judge said the show, which ran from 2002-2005, took a heavy toll on her family life, reported Radar online.
Sharon, 61, said the demands of outrageous show meant she and rocker husband Ozzy Osbourne did not spend enough time with daughter Kelly and son Jack.
"It was the biggest mistake I ever did, but would I have wanted to live a lesser life? You make the most of what you have. I don't know how, but Jack and Kelly came out just great," she said.
The TV hostess said she moved out because of his drinking and drug use, but now he is clean and sober.
"He stopped because he knows what he was going to lose, not just me but everything. He says we're like bread and butter. We fit together so perfectly.