Dolce had called children conceived by same-sex parents via IVF "synthetic", while Gabbana had said, "The family is not a fad. In it there is a supernatural sense of belonging."
Celebrities urged a boycott of Dolce & Gabbana products in response to their comments.
The designers, who were a couple for 20 years, have now clarified their stand in an interview with CNN.
"I respect you because you choose what you want. I respect me because I choose what I want... This just my point of private view," Dolce said.
The duo's comments to an Italian magazine sparked controversy with stars like Elton John, Ryan Murphy and Madonna criticising him. John and Murphy even called for a boycott of the brand.