Aniston, 45, has been in a relationship with the actor-director since 2011. They got engaged in 2012.
She said initially she used to pay attention to the rumours but now she does not care about them because of the trust between them, reported People magazine.
"(I) just don't pay attention. I think I used to really, there was a period where I was hell-bent on saying, 'That's not true, that's not right, that's not fair.' And now I just think you have to let it roll off your back and you realise, I think everyone knows it's all B S and like soap opera on paper."