The company was found liable in 2013 by a Kansas jury of allegedly conspiring to fix prices for polyurethane, an industrial chemical used in everything from packaging to car interiors.
The judgment dealt with the alleged company actions between 2000 and 2003. Dow had petitioned the Supreme Court to reconsider the judgment.
But the company said today the court's current lineup has "increased the likelihood for unfavorable outcomes for business involved in class action suits."
Dow said the settlement would benefit shareholders. "While Dow is settling this case, it continues to strongly believe that it was not part of any conspiracy and the judgment was fundamentally flawed as a matter of class action law," the company said in a statement.