The raids targeted a vehicle and a container loaded with weapons late yesterday at the port of Mukalla, the provincial capital of Hadramawt, the local official said.
The strikes destroyed the arms container, he added.
The deaths bring to 23 the number of suspected Al-Qaeda militants killed by similar strikes in Yemen in less than three weeks, and follows the death of the second-in-command of Al-Qaeda's global network.
The group confirmed on June 16 the killing of Nasir al-Wuhayshi, who headed Al-Qaeda's Yemen branch, by US drone strike.
The US still has drones and other aircraft at bases in Saudi Arabia and Djibouti.
AQAP was behind several plots against Western targets and claimed the January massacre at French satirical magazine Charlie Hebdo.