Drug that prevents stroke closer to reality

A drug that mimics some actions of the hormone oestrogen may have the potential to reduce and even stop the effects of stroke, Australian scientists claim.
Researchers at Monash University's Faculty of Biomedical and Psychological Sciences studied a little known oestrogen receptor that occurs in men and women.
They have found that by blocking this receptor in males they can alleviate the symptoms of stroke if given up to four hours after the event.
However - they have also shown that - by triggering this receptor in older women, it has the potential to protect females from the harmful effects of stroke.

It is the first time that a drug with the potential to reduce and even stop the effect of a stroke in a sex-specific manner has been found and is considered a significant breakthrough in stroke research, researchers said.
According to Associate Professor Chris Sobey, it has been well known in the past that there are two receptors for oestrogen.

However in the last decade a third oestrogen receptor was found in heart, blood vessels and brain tissue.
Sobey, Dr Brad Broughton and their team discovered that the receptor behaves completely differently in males and females following a stroke.
Using mouse models, researchers found that the receptor - called GPER - when triggered following a stroke makes the stroke outcome worse in older males but better in older females.

Targeting the receptor has no effect in younger females, presumably because of the competing effects of high levels of oestrogen naturally present, "which is fine because we are essentially looking at women who are post-menopausal as the main female patients who suffer strokes," Sobey said.
The researchers have also found the same pattern exists for changes in receptor levels in both mouse and human brain tissue in stroke victims as well as controls, opening the way for new ways to effectively treat the disease, depending on the gender of the patient.
"It is quite conceivable that a post-menopausal woman presenting at the ER with a stroke would be treated by stimulating this receptor through a targeted drug, whereas a man of similar age would receive a GPER blocker - each respective treatment should similarly halt the symptoms of the stroke," Sobey said.

The results have been published in the international journal, Stroke.