Du Plessis made 77 not out off 92 balls balls as South Africa reached 203 for three in their second innings at lunch, an overall lead of 379.
In the fastest scoring of the match, Du Plessis and Temba Bavuma (64 not out) added 133 runs off 149 balls in an unbeaten fourth wicket partnership. South Africa scored 149 runs for the loss of Hashim Amla's wicket in 29.1 overs during the morning.
Bavuma made a slow start to the day and survived a chance on eight when Imrul Kayes dropped a fierce square cut at point off Shafiul Islam. But he lifted his tempo as he and Du Plessis mixed boundaries with good running between the wickets. Bavuma had faced 85 balls by the interval.
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