"Dutch F-16s carried out around 10 missions over Iraq and eastern Syria," the Hague-based ministry said in its weekly summary of operations on its website.
It is the first time the summary has mentioned targets in Syria since the Dutch government late last month announced it was fanning out its current air support mission over Iraq into Syria, in the wake of US and French requests.
The air strikes were directed against "combat positions, military equipment and strategic aims of the IS terror organisation," the ministry said, without detailing when and where the attacks took place.
Late last year in the wake of the November Paris attacks, the Dutch government received a request from US and French allies to broaden its campaign against the IS jihadist group - also known by the acronym ISIS.
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Dutch Prime Minister Mark Rutte in January said the extended air operations would target eastern Syria "in particular to stop the IS 'pipeline' leading from Syria into Iraq."
US air strikes in Iraq began in August 2014 after IS captured a swathe of territory in Iraq and Syria in a lightning offensive.
The four Dutch F-16 jet fighters which have been pounding IS jihadists in Iraq since October 2014 will "remain active until July 1 over the enlarged zone," the government said last month.
Dutch Foreign Minister Bert Koenders has cautioned however that bombing was not the whole solution in a "complex conflict" in Syria.
More than 260,000 people have been killed in Syria's conflict and more than half the population has been displaced.