Andres Iniesta's strike four minutes from the end of extra-time in the Johannesburg final crowned Spain as world champions for the first time and now, four years later, the European giants clash again at Salvador's Arena Fonte Nova in the mouth-watering opening match of Group B.
With South American dark horses Chile and Australia still to come, a win for either side would set the group's agenda.
Captain Robin van Persie, Arjen Robben, Wesley Sneijder, Nigel De Jong and Dirk Kuyt are the five survivors from the 2010 final in the current squad and the Dutch have made no secret of their desire for revenge.
"It should always burn inside to make something right. To play against them now in the first game is a great challenge."
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Veteran midfielder Wesley Sneijder, who will win his 100th cap in the match, said the wounds of that defeat were still raw.
"It's like a scar that hasn't yet healed. It always gets me down when I think about it," said the Galatasaray star.
As the double European and reigning world champions, Vicente del Bosque's Spain are bidding to join Brazil and Italy as the only teams to have enjoyed back-to-back World Cup wins.
- No fear, just respect -
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Cesc Fabregas should start up front for Spain with Brazil-born Atletico Madrid striker Diego Costa expected to make a second-half appearance from the bench.