The draw for the quarter-finals was made at AFC headquarters in Kuala Lumpur today.
East Bengal have reached the last eight for only the second time in seven tournament appearances. Semen Padang, on the other hand, are tournament debutants.
Defending champions Kuwait Sports Club face New Radiant of Maldives in the quarterfinals.
The first leg of the AFC Cup quarter-finals will be held on September 17 with the return fixtures taking place one week later.