Yuki, who is coming into the event with a title win at a Challenger tourament in Australia, eased past his Ubzek rival 6-1 6-4 in just 59 minutes at R K Khanna Tennis stadium.
After being outplayed in first set, which lasted just 19 minutes, Shofayziyev curbed his errors even as his power-packed strokes lacked precision.
His sent down some powerful serves in the second set but struggled with his backhand returns.
There were only two games when the match looked like a contest -- second game of the second set when Shofayziyev held at 15 and the last game when the longest rally of the match was played. The Uzbek came back from 0-30, kept Yuki engaged in four deuces but finally buried a forehand to net at second match point to hand the Delhi boy win.
Yuki said he was delighted to play in his home city after a gap of two years. He also said that he needs to improve on his net play as he targets winning the wild card tourament for Australian Open next week in China.