The funnyman and his model girlfriend Paige Butcher, 36, are expecting their first child together, his representative confirmed on the show Entertainment Tonight.
Butcher is due to give birth in May next year.
The baby will be her first, while Murphy has five children with his first wife Nicole.
He also has a son by each of his exes Tamara Hood and Paulette MCNeely, in addition to a daughter, named Angel, with former Spice Girls singer Melanie Brown.
The actor has been dating blonde beauty Butcher since 2012.