NASA paid glowing tribute to Mitchell, who died in Florida after a brief illness late Thursday, the eve of the 45th anniversary of his lunar landing.
The late astronaut was a member of the 1971 Apollo 14 mission along with Alan Shepard Jr. And Stuart Roosa.
Mitchell was the last Apollo 14 survivor: Roosa died in 1994 and Shepard in 1998.
NASA Administrator Charles Bolden recalled Mitchell marveling at the stunning view of Earth from space.
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"'It takes more than a moment to fully realize this is Earth... Home.'
"He believed in exploration, having been drawn to NASA by President Kennedy's call to send humans to the Moon. He is one of the pioneers in space exploration on whose shoulders we now stand."
Mitchell was in charge of piloting the Antares lunar module, which landed in the Fra Mauro region of the Moon.
It was the third manned mission to the Moon and Mitchell became the sixth human to walk on the lunar surface.
During the mission the astronauts collected 100 pounds (40 kilos) of lunar rock samples and carried out a series of experiments.
The mission ended when the astronauts, traveling aboard a space capsule, splashed down in the Pacific Ocean on February 9, 1971.
He said he believed that extra-terrestrial unidentified flying objects (UFOs) had visited the Earth, but acknowledged that he had never seen one.
Mitchell was the author of several books, including his 1996 memoir, "The Way of the Explorer."
Two daughters, three adopted sons and nine grandchildren are among family who survive him.
The family told The Palm Beach Post newspaper that Mitchell died at a West Palm Beach hospital after a short illness.