One Nitin, studying Journalism at the university and Rajsimha, a former student of the institute, were arrested, Assistant Commissioner of Police (Kachiguda Division) S Sudhakar told PTI.
"The alleged incident occurred on the night of October 31 and the girl, who was known to the accused, was apparently drugged and then sexually assaulted at a room on the university premises," the ACP said.
The victim lodged a complaint this morning, Osmania University police station Inspector V Ashok Reddy said.
She has been sent for medical examination, he added.