The ministry says today's collision took place on a main road linking the town of Beni Suef with the capital, Cairo.
Egypt's state-run news agency MENA cited an unnamed health official as saying three of the injured were in serious condition and in intensive cares.
The bus, owned by a private tourist company, was carrying 62 passengers. Tourist buses are often leased and used for inter-city commuter traffic in low season.
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