Egypt has seen a spike in attacks since the overthrow of Islamist President Mohammed Morsi in a military coup last July, often targeting security forces. Many have been claimed by a Sinai-based, al-Qaida-inspired militant group.
Meanwhile, pro-Morsi protesters have staged near-daily demonstrations to demand his reinstatement, with the largest rallies usually on Friday or key anniversaries, though their numbers have dwindled in recent months.
In the oasis town of Fayoum, 80 kilometres (50 miles) southwest of Cairo, clashes with security forces erupted during a rally today by supporters of the Brotherhood, from which Morsi hails.
Hospital officials said one person was shot in the back and died immediately. It was not clear whether he was a demonstrator or a resident of the area.
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The state news agency MENA quoted an Interior Ministry spokesman as saying the explosions hit a truck belonging to the Central Security forces that was stationed on the bridge leading into a major square. A security official said four of the wounded were members of the police.
Shortly after the bombing, Prime Minister Hazem el-Beblawi said that "terrorist" attacks will not deter Egyptians from taking "steps toward their future" in a statement carried on MENA.
Amid the increasing attacks, Egypt has seen a heavy security deployment on the streets around main squares and government installations, in anticipation of more violence. The Brotherhood is also planning a series of marches in the run up to next Tuesday, the third anniversary of the day on which long-time autocrat Hosni Mubarak stepped down following the country's 2011 uprising.