With an economy battered by three years of unrest, successive governments had said that the subsidies which allow Egyptians to buy gasoline at some of the world's cheapest prices must be lifted.
But the authorities had shied away from implementing the cuts fearing a public backlash, something that Sisi, elected in May, has said would not prevent him from slashing state spending.
The government decree raised the price of 92 octane gasoline late yesterday, which sold at 1.85 pounds (USD 0.36) a litre, to 2.6 pounds, and 80 octane gas from 0.9 pounds to 1.6 pounds a litre, the official MENA news agency reported.
The price increase are in effect since midnight yesterday, the state-owned Al-Ahram newspaper reported on its website.
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The state spends more than 30 per cent of its budget on fuel and food subsidies, in a country were nearly 40 per cent of the population -- some 34 million people -- hover around the poverty line.
Interim premier Ibrahim Mahlab has said that subsidies on oil cost the exchequer USD 22 billion, against an annual education and health budget of USD 9.8 billion.
Sisi, a former army chief who came to power in elections after overthrowing Islamist president Mohamed Morsi a year ago, preaches a message of austerity and self sacrifice to restore the economy.
The government has also signed off on a capital gains tax and said it would gradually raise electricity prices over the next five years.
Sisi won the May election by about 97 per cent of the vote against a weak leftist candidate, and many view him as a strong leader who can kickstart a recovery.
But Morsi's Muslim Brotherhood movement, decimated in a brutal crackdown after his overthrow, still holds near daily protests it hopes will grow with increasing economic discontent.
The country has just began to recover when the military, prompted by huge protests, overthrew Morsi in July last year.
Since then Egypt has been rocked by bloody street clashes and militant attacks in which almost 2,000 people have been killed.