"Yes, the matter has been decided and I have no choice but to respond to the call of the Egyptian people," Sisi, also the Defence Minister, was quoted as saying by Kuwaiti newspaper Al-Seyassah.
"The call (of the Egyptians) has been heard everywhere and I will not reject it. I will seek a renewal of confidence of the people through free voting," he said when asked if he would run for the presidential election.
Sisi, widely popular for overthrowing the Islamist regime linked to now outlawed Muslim Brotherhood, is expected to win the polls easily with no serious rivals.
His victory would mark the return of a military man to the helm of power since the overthrow of the monarchy in 1952. Longtime president Hosni Mubarak, who was ousted in a popular uprising three years ago, was an ex-air force chief.
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"We don't have a magic wand but we will not tamper with the people's dreams and aspirations. Let's hold our hands together and work for the country," he said.
Sisi is expected to step down as the army chief before contesting election scheduled to be held between February 17 and April 18.
Sisi said that if he wins he would call for a pan-Arab alliance to fight against growing "terrorism" in the region.
"We will call for an Arab union based on mutual cooperation between countries suffering from terrorism so we can wage a common war against it," Sisi said.