The strike occurred late yesterday in volatile Sajawal Kala near Tarin Kot, the capital of Uruzgan, a poppy-growing province where the Taliban have a heavy presence.
"At least eight people, all civilians, were wounded" in the strike and brought to a government hospital in Tarin Kot, said Zia-ul-Rahman, a doctor in the hospital.
"Among the victims were five women, two children and a young man," he told AFP.
Rahman blamed the strike on "foreign forces". There was no immediate statement from either the US or NATO on the incident.
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Civilian casualties caused by NATO forces have been one of the most contentious issues in the 15-year campaign against the insurgents, prompting strong public and government criticism.
In February this year, a US airstrike in volatile Sangin of Helmand province killed at least 18 civilians, mostly women and children.
In November last year, 32 Afghan civilians were killed in a US airstrike in volatile northeastern province of Kunduz.