The incident occurred at around 8:30 AM when the Andhra Pradesh State Road Transport Corporation (APSRTC) bus was going to Penukonda from Madakasira in the district, Anantapur District Superintendent of Police Rajsekhar Babu said.
"As per the information available, at least eight people were killed in the mishap. Police personnel are carrying out rescue operation," Babu told PTI over phone.
The injured have been shifted to different hospitals in Hindupur and Anantapur, Joint Collector S Satyanarayan said.