The International Organisation of Vine and Wine (OIV) estimated this year's output at 259 million hectolitres, a year-on-year drop of five per cent.
This worldwide annual total, released at a news conference in Paris, is among the three lowest since 2000.
OIV said weather was partly to blame. "The El Nino climate phenomenon seems to be back in Latin America, where production was affected by fairly exceptional weather, with lots of rain," said IOV's CEO, Jean-Marie Aurand.
As it recedes the Pacific cooling trend known as La Nina typically begins, often causing increased rainfall, storms and snow across the globe.
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Most of the fall in wine output occurred in the southern hemisphere: Argentina's production fell by 35 per cent to 8.8 Mhl, leading its world ranking to drop from fifth to ninth place.
In Chile it fell by 21 per cent, to 10.1 Mhl, and in Brazil it halved, to 1.4 Mhl.
A prolonged drought in South Africa pushed production there below 10 Mhl for the first time since 2011, to 9.1 Mhl, a drop of 19 per cent.
China climbed the global output ranks to sixth place without actually increasing its production (11.5 Mhl) thanks to the drops in Latin America, said Aurand, adding that China planned to boost output to 16 Mhl by 2020 by developing vineyards near the Gobi desert.
In Europe, Italy confirmed its place as the leading world producer with 48.8 Mhl, having knocked France off the top spot in 2015.
Of the top three producing nations, the OIV expects only Spain to show growth in 2016, with a one-per cent year-on-year rise to 37.8 Mhl.
The United States is fourth with 22.5 Mhl, a rise of two per cent, and Australia is the world's fifth-largest producer after seeing five per cent growth to 12.5 Mhl.
The OIV estimated that between eight and 12 per cent of wine was produced organically in 2016 and that the trend was catching on "almost everwhere".
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