The World Meteorological Organization said El Nino, which occurs every two to seven years, had resurfaced a few months ago, become "mature and strong", and was expected to become even more powerful by the end of the year.
"Severe droughts and devastating flooding being experienced throughout the tropics and sub-tropical zones bear the hallmarks of this El Nino, which is the strongest in more than 15 years," WMO chief Michel Jarraud said in a statement.
The UN agency said this year's event was expected to push water surface temperatures in the east-central Pacific Ocean more than two degrees Celsius above normal, making it one of the four strongest El Ninos since 1950.
Previous particularly strong El Ninos occurred in 1972-73, 1982-83 and 1997-98.
More From This Section
Typically, El Nino events reach their maximum strength between October and January, but often continue to wreak havoc through the first quarter of the year.
In recent months, bone-dry conditions caused by the El Nino have sparked some of the worst forest fires in Indonesia's history.
The phenomenon also often leads to heavier rainfall in the eastern Pacific and South American nations, raising the spectre of floods and landslides.
WMO linked this year's El Nino to the "very active tropical cyclone season" in the Pacific, including the record-breaking Hurricane Patricia that hit Mexico last month.
The UN meanwhile warned last week that El Nino could significantly increase the number of people going hungry, as countries like Sudan, Eritrea, Ethiopia and Djibouti are expected to see drier conditions, and others, including Kenya, Somalia and Uganda are at risk of floods.