The former army general has faced widespread international criticism for his ouster last year of Egypt's first freely elected president and his ferocious crackdown on Islamists that has killed more than 1,000 and imprisoned more than 20,000.
A year later, after el-Sissi's election as president, his critics fear he is leading his country into autocracy, with pro-democracy dissenters jailed or silenced.
But in an interview with The Associated Press, his first with the foreign media since he took office in June, el-Sissi insists all his actions were to combat militancy and save the country from civil war.
"More than a year ago, I warned that the region was heading to great danger from extremist thought," he said. "It didn't receive proper attention until the events in Iraq took place and the Islamic State swept over the Iraqi-Syrian borders."
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His approach, however, has raised concerns over the potential for democracy in Egypt.
El-Sissi and his supporters effectively group the Muslim Brotherhood, an organization that won repeated elections over the past three years, as equivalent to hardline militant groups wreaking havoc from Libya to Iraq.
Washington is looking for support by Arab nations for its strategy to strike the Islamic State group. But at the same time, it has been critical of Egypt's crackdown on Islamists, withdrawing some military aid and straining a longtime alliance.
El-Sissi makes his first visit to the United States as president to attend the UN General Assembly in the coming week. So far there are no plans for talks with President Barack Obama.
Asked if Egypt might provide airspace access or logistical support for airstrikes, he said, "We are completely committed to giving support. We will do whatever is required.