Rowell Lyngdoh and Roytre C Laloo, hand-picked by Chief Minister Mukul Sangma, will hold the post of deputy chief ministers.
Three women Ampareen Lyngdoh, Roshan Warjri and Deborah C Marak also took the oath of office administered by Governor R S Mooshahary.
Among others, Clement Marak and Sniawbhalang Dhar were made ministers, while H D R Lyngdoh, P Tynsong and A L Hek were retained from the previous cabinet.
The chief minister's brother Zenith Sangma also took the oath of office.
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Meghalaya can have a maximum of 12 ministers, including the chief minister.
The Congress had won a total of 29 seats, two short of absolute majority in the 60-member House.
Twelve independent MLAs also support the government.