Based on Margaret Atwood's novel of the same name, the series is set to begin production later this year, with the author herself serving as consulting producer, said the Hollywood Reporter.
The series will be the first collaboration from Hulu and studio MGM. Originally, Hulu purchased the script for the series from writer Ilene Chaiken, however she later became unavailable for the project after becoming showrunner on Fox's "Empire".
Moss, 33, will play Offred, a Handmaiden who is one of the few remaining fertile women left in Gilead.
Offred must learn to survive in the terrifying regime, while at the same time trying to find the daughter that was taken from her.