The "Finding Dory" star, who hosts her own top-rated daytime talk show in America, picked up her 20th, 21st and 22nd awards at the Microsoft Theater.
Singer-actor Justin Timberlake presented her with the favourite daytime TV host and favourite animated movie voice trophies, while her sketch romp around a shopping mall with Britney Spears, which aired on her show last year, earned her the favourite comedic collaboration prize.
Handing her another three honours, Timberlake called Ellen "one of my very good friends" and "one of the best people on this planet".
"And everybody keeps thanking the people and it's redundant but you are the people who are responsible for me being up there so I say thank you people."
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DeGeneres' "Finding Dory" film was also named favourite movie and favourite family movie at the ceremony.
Timberlake was also a big winner at the awards bash, picking up favourite male artist and favourite song for "Can't Stop The Feeling."
It was also a huge night for girl group Fifth Harmony, who performed for the first time as a four-piece.
The quartet wowed the audience and viewers at home by wearing revealing black leather outfits for a raunchy rendition of their "Work From Home" hit.
The band, who also picked up the favourite group prize for a second successive year, were stunned by the departure of Camila Cabello last month.
Other big winners from the worlds of movies, TV, music and social media included Tom Hanks (favourite dramatic movie actor), Kevin Hart (favourite comedic movie actor), Melissa McCarthy (favourite comedic movie actor) and Indian actress Priyanka Chopra (favourite dramatic TV actress).
Jennifer Lawrence (favourite movie actress), 'The Big Bang Theory' (favourite network TV comedy), Sofia Vergara (favourite comedic TV actress) and Jennifer Lopez (favourite TV crime drama actress) were also named winners.
Matt LeBlanc and Kristen Bell won favourite actor in a new TV series male and female respectively.
Carrie Underwood (favourite country female artist), Niall Horan (favourite breakout artist) and Britney Spears (favourite female artist) were also among winners.