Unai Emery is fighting for his future at Arsenal while Everton boss Marco Silva and West Ham manager Manuel Pellegrini are running out of time.
Emery is the bookies' favourite to be the third Premier League manager to lose his job this season after the dismissals of Watford's Javi Gracia and Mauricio Pochettino by Spurs.
His future looked even bleaker on Thursday with a 2-1 home defeat to Eintracht Frankfurt in the Europa League.
Everton, according to reports, have held board-level discussions about Silva's position while Pellegrini has gone two months without a win in any competition for his misfiring Hammers.
AFP Sport looks at the three managers fighting for their lives in the Premier League this weekend.
Emery stumbles
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"My work and my job is firstly analysing the match, how we are in the Europa League, how we are going to play on Sunday."
Everton search for Silva lining
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"Yes it's difficult to bring someone in with that nightmare run of games but the fans need hope. Players need a fresh start & ideas to give us a slight chance to pick up points."
Pellegrini's Chelsea test
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"Football changes all the time. We are working to try to beat Chelsea and after that, we will see the result."