Arsenal's bad luck with defensive injuries was summed up when the welcome return of Sokratis in the midweek Europa League victory against BATE Borisov came at the expense of another setback for Laurent Koscielny.
Manager Unai Emery hopes French defender Koscielny, who returned from a long-term achilles injury in December, will recover in time to face struggling Southampton at the Emirates Stadium on Sunday.
The Arsenal boss is desperate for his side to discover a degree of consistency, which has been missing since they visited St Mary's Stadium for the first meeting of the season between the two clubs in mid-December.
Manchester United, currently occupying fourth place in the Premier League, are just one point ahead of Emery's side and face high-flying Liverpool on Sunday, with sixth-placed Chelsea involved in the League Cup final against Manchester City, giving Arsenal a chance to clamber back into the top four.
But to do so, they must avoid a repeat of the display that allowed Southampton to claim a 3-2 victory that brought an end to Arsenal's 22-game unbeaten run, which had helped Emery establish himself at his new club.
Since then results have been anything but steady, while the manner of that defeat highlighted defensive flaws that have become more prominent as the Gunners attempt to keep pace with their rivals in the battle to finish in the Champions League places.
In the 14 games since then they have won just seven times in all competitions, while they have alternated between victory and defeat in their past nine outings. Frequent disruptions to the line-up, particularly in defence, have done nothing to help.
- Injury blight -
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"We need to improve, we need to work harder but we have also to be lucky and not have a lot of injuries because when you do it is difficult for the team, for you and when you come back the difference is not the same when you change every week."