The 'Rap God' rapper took away the award for 'Artist of the Year' after performing the track from his latest album The Marshall Mathers LP 2.
Whilt Swift's 'I Knew You Were Trouble' scored the 'YouTube Phenomenon' award. Macklemore and Ryan Lewis received the gong for 'YouTube Breakthrough'.
South Korean girl group Girls' Generation won 'Video of the Year' for 'I Got A Boy', with vocalist Tiffany collecting the accolade on stage.
The show featured numerous performances from artists including Lady Gaga, Arcade Fire, Avicii and MIA, as well as Tinie Tempah, Conor Maynard and Dizzee Rascal who performed from London.