Directed by Lee Daniels, the ad features cast members Taraji P Henson, Bryshere Gray, Trai and Grace Byers, Jussie Smollett, Gabourey Sidibe and Tasha Smith, said the Hollywood Reporter.
Terrence Howard, however, is not a part of the ad.
"What will I tell my son? What will you tell your daughter? What will we tell our future generation?," Henson says in the beginning of the ad.
The stars reference Donald Trump, with Trai Byers saying, "The violence and nasty rhetoric against mankind is unacceptable."
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Daniels, in the video, also requests people to exercise their voting rights.
"So many women and men died for us to have the right to vote. Every time we sit out, we dishonor their sacrifices."
Clinton and Trump will fight it out again in the second presidential debate on Sunday.