A middle-aged man, who was suffering from the disease for last of couple of weeks, died late last night at the NBMC, the official said.
Out of the 21 deaths, 14 were due to acute Encephalitis and seven due to Japanese Encephalitis, he added.
Stating that there was "nothing to panic" about the disease, the health officer said the state government this year has taken all necessary precautionary measures to control it.
Incidentally, last year over 200 deaths due to different types of encephalitis were recorded in the state.