An awareness of the one-way journey and all possible dangers cannot be simulated on the International Space Station (ISS), or even in Antarctica, one of the most remote places on Earth and a frequently cited zone in space analogue studies, researchers said.
"We can not simulate the same physical and environmental conditions to reconstruct the martian environment, I mean such traits like martian microgravitation or radiation exposure," said Konrad Szocik, a cognitive scientist at the University of Information Technology and Management in Poland.
He argued that it may be necessary to modify people's bodies and minds ahead of journeying to Mars.
Electronically enhancing the human senses or prescribing medication might help diminish emotional reactions in a moment a crisis, Szocik said.
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While most discussions of colonies focus on the technological or financial challenges of constructing and maintaining a Mars colony, there has been less study of the social aspects of putting people within a martian colony.
"Group problems affect many challenges and troubles, and we should consider now how we can prevent such typical human problems like conflicts, wars, cheating, etc," Szocik was quoted as saying by the 'Seeker'.
Medical officials should consider how to reduce the likely mortality rate from disease, possible technological failures and radiation from the martian environment, among other factors, he said.
The study was published journal Space Policy.