The 'Hero' hitmaker scooped awards including best Pop/Rock Artist and several music prizes for 'El Perdedor', his track with Marco Antonio Solis, while Santos scooped the Favorite Video prize for Propuesta Indecente among others, reported Deadline.
Iglesias also took home the special Supernova prize for his career achievements.
Marc Anthony was honoured for his Vivir Mi Vida Tour, while other winners included Bruno Mars (Favorite Hitmaker) and Pitbull (Urban Artist).
Performers included Iglesias, Jenni Rivera's daughter Chiquis, and Latin star Wisin, who took to the stage with holograms of Ricky Martin and Jennifer Lopez at the BankUnited Center venue.