After piloting the state-owned Gulf airline through more than a decade of growth, Hogan will leave his post in the second half of 2017, Etihad Aviation Group said in a statement.
Hogan was the architect of a strategy that saw Etihad buy significant stakes and make major investments in other airlines, notably Air Berlin and the long-struggling Alitalia.
But Etihad Aviation Group chairman Mohamed al-Mazrouei said it was time for a company-wide review, following continued cash injections into Etihad's partners.
"We must ensure that the airline is the right size and the right shape."
More From This Section
Hogan's approach was in stark contrast to the strategies of fellow Gulf airlines Emirates, based in Dubai, and Qatar Airways, which instead invested in developing their own services.
It saw Etihad spend hundreds of millions on stakes in foreign airlines, including acquisitions of 49 per cent of Alitalia, 29 per cent of Air Berlin, 19.9 per cent of Virgin Australia and three per cent of Irish carrier Aer Lingus that it offloaded in 2015.
Some of the investments have been costly, however, with Etihad keeping Air Berlin alive with regular cash injections in recent years. The German carrier suffered a record loss of 447 million euros (USD 480 million) in 2015.
Etihad's management of Alitalia has also been criticised over fears of up to 1,600 jobs being cut at the Italian carrier, which was rescued from bankruptcy by the Abu Dhabi company in 2014.
Etihad reported a 41 percent surge in its net profit in 2015, reaching USD 103 million on the back of rising passenger numbers and cargo volumes.