Etihad Airways daily flies three scheduled flights between Abu Dhabi and Cairo and the fourth one will start from March 27.
"Etihad Airways is focused on offering guests more choice. Attracting both commercial and leisure business, the additional flights linking Cairo and Abu Dhabi with connections beyond will help cater for the growing demand on one of our most popular North African and global routes, said Kevin Knight, Etihad Airways' Chief Strategy and Planning Officer.
GCC includes contries like Saudi Arabia, Kuwait, United Arab Emirates, Qatar, Bahrain and Oman.
The route has grown to become one of the most popular in Etihad Airways' network, building on strong commercial ties between the capital cities of the UAE and Egypt.
Over two million guests have flown on the Cairo route since its launch in 2004, becoming a key market among the 116 global destinations served by Etihad Airways.