"If they wanted to change their decision, of course they would find open doors, but I think it's not very likely," Schaeuble told Bloomberg Television in his first public comments on last week's election in Britain which saw Prime Minister Theresa May lose her parliamentary majority.
He noted a pro-European surge in France for President Emmanuel Macron and a youth vote in Britain that swung sharply to the left-wing Labour Party, in favour of closer post-Brexit ties, as proof of greater EU support among the young.
"It would not be helpful if we started speculation... We take it as a matter of fact, it's a matter of respect."
The British government has been in disarray since a snap election last Thursday, called by May in an effort to boost her majority but which resulted in a hung parliament.
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May is scrambling to strike a deal for the support of the Northern Irish Democratic Unionist Party's (DUP) 10 lawmakers, but the clock is ticking on the two-year EU exit talks period she triggered in late March.
"Let's start the negotiation," Schaeuble told Bloomberg today.
"We will minimise the potential damage and maximise the mutual benefit... At the end we will always come to reasonable decisions.