The 28-nation bloc said it was adding 18 persons and one entity to its asset freeze and travel ban blacklist, complementing measures adopted by the UN against the Democratic People's Republic of Korea, the north's official name.
"The persons subjected to restrictive measures ... Are mostly high-ranked military officials involved in key bodies responsible for supporting or promoting the DPRK's nuclear-related, ballistic missile-related or other weapons of mass destruction-related programmes," the EU said in a statement.
The European Council, which groups EU member states, said the decision means sanctions are now in place against 66 individuals and 42 entities in North Korea.
The new names will be published on Friday.
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In March, the UN Security Council imposed the toughest sanctions yet against Pyongyang, including unprecedented inspections of all cargo to and from the notoriously reclusive country which has locked itself away from the rest of the world for the past 60 years.
The EU established diplomatic relations with North Korea in 2001 but contacts are minimal. It adopted its first sanctions in 2006.