The new team based at Europol's headquarters in The Hague will analyze and share intelligence gathered by the EU border agency Frontex, Interpol and EU member police forces to identify and track smuggling networks.
In an example of the work the team will do, Europol announced it had helped Greek authorities who arrested 16 suspected human traffickers last week.
The suspects are accused of arranging travel for 350 migrants, mostly Syrians, who paid up to 9,000 euros (USD 9,500) each to get from Turkey to the Greek islands and then onward to mainland Europe using forged travel documents.
The scale of the human trafficking trade is vast and the risks are high for migrants desperate to reach Europe. Europol says 220,000 migrants crossed the Mediterranean last year, costing 3,000 migrants their lives. A further 1,000 have died already this year.
Linking with Interpol gives the Europol team intelligence beyond Europe's borders and into the chaotic North African region that is the jumping off point for many migrants fleeing conflicts in countries like Syria and Iraq.